PEGylation refers to change in structure of protein by linking one or more polyethylene glycol (PEG) chains. It is easily soluble in organic and aqueous solutions and is non-toxic in nature. The chain binds to the drugs covalently and make it sterically stable. The polymer thus formed is non-toxic, non-antigenic, non-immunogenic, and highly water soluble. It further increases half-life of the drug and reduces dose frequency by preventing renal excretion of drugs. 更多
